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==Crystal structure of the kinase domain of Gilgamesh isoform I from Drosophila melanogaster==
==Crystal structure of the kinase domain of Gilgamesh isoform I from Drosophila melanogaster==
<StructureSection load='4nt4' size='340' side='right' caption='[[4nt4]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
<StructureSection load='4nt4' size='340' side='right'caption='[[4nt4]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nt4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NT4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nt4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NT4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG6963, Dmel_CG6963, gish ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4nt4 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nt4 OCA], [https://pdbe.org/4nt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4nt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nt4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q86NK8_DROME Q86NK8_DROME]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The CK1 family kinases regulate multiple cellular aspects and play important roles in Wnt/Wingless and Hedgehog signalling. The kinase domain of Drosophila Gilgamesh isoform I (Gilgamesh-I), a homologue of human CK1-gamma, was purified and crystallized. Crystals of methylated Gilgamesh-I kinase domain with a D210A mutation diffracted to 2.85 A resolution and belonged to space group P43212, with unit-cell parameters a = b = 52.025, c = 291.727 A. The structure of Gilgamesh-I kinase domain, which was determined by molecular replacement, has conserved catalytic elements and an active conformation. Structural comparison indicates that an extended loop between the alpha1 helix and the beta4 strand exists in the Gilgamesh-I kinase domain. This extended loop may regulate the activity and function of Gilgamesh-I.
Structure of the kinase domain of Gilgamesh from Drosophila melanogaster.,Han N, Chen C, Shi Z, Cheng D Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):438-43. doi:, 10.1107/S2053230X14004774. Epub 2014 Mar 25. PMID:24699734<ref>PMID:24699734</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4nt4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Chen, C C]]
[[Category: Large Structures]]
[[Category: Shi, Z B]]
[[Category: Chen CC]]
[[Category: Zhou, Z C]]
[[Category: Shi ZB]]
[[Category: Serine/threonine protein kinase]]
[[Category: Zhou ZC]]
[[Category: Transferase]]
[[Category: Wnt signaling pathway]]
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