4bqg: Difference between revisions
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==structure of HSP90 with an inhibitor bound== | ==structure of HSP90 with an inhibitor bound== | ||
<StructureSection load='4bqg' size='340' side='right' caption='[[4bqg]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4bqg' size='340' side='right'caption='[[4bqg]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bqg]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4bqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQG FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=50Q:5-(3,4-DICHLORO-PHENOXY)-BENZENE-1,3-DIOL'>50Q</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqg OCA], [https://pdbe.org/4bqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqg RCSB], [https://www.ebi.ac.uk/pdbsum/4bqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4bqg" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Heat Shock Protein structures|Heat Shock Protein structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Amboldi | [[Category: Large Structures]] | ||
[[Category: Bindi | [[Category: Amboldi N]] | ||
[[Category: Brasca | [[Category: Bindi S]] | ||
[[Category: Caronni | [[Category: Brasca MG]] | ||
[[Category: Casale | [[Category: Caronni D]] | ||
[[Category: Ceccarelli | [[Category: Casale E]] | ||
[[Category: Colombo | [[Category: Ceccarelli W]] | ||
[[Category: DePonti | [[Category: Colombo N]] | ||
[[Category: Donati | [[Category: DePonti A]] | ||
[[Category: Ermoli | [[Category: Donati D]] | ||
[[Category: Fachin | [[Category: Ermoli A]] | ||
[[Category: Felder | [[Category: Fachin G]] | ||
[[Category: Ferguson | [[Category: Felder ER]] | ||
[[Category: Fiorelli | [[Category: Ferguson RD]] | ||
[[Category: Fogliatto | [[Category: Fiorelli C]] | ||
[[Category: Guanci | [[Category: Fogliatto G]] | ||
[[Category: Isacchi | [[Category: Guanci M]] | ||
[[Category: Mantegani | [[Category: Isacchi A]] | ||
[[Category: Pesenti | [[Category: Mantegani S]] | ||
[[Category: Polucci | [[Category: Pesenti E]] | ||
[[Category: Riceputi | [[Category: Polucci P]] | ||
[[Category: Sola | [[Category: Riceputi L]] | ||
[[Category: Visco | [[Category: Sola F]] | ||
[[Category: Zuccotto | [[Category: Visco C]] | ||
[[Category: Zuccotto F]] | |||
