2cl8: Difference between revisions

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[[Image:2cl8.gif|left|200px]]<br />
<applet load="2cl8" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cl8, resolution 2.80&Aring;" />
'''DECTIN-1 IN COMPLEX WITH BETA-GLUCAN'''<br />


==About this Structure==
==Dectin-1 in complex with beta-glucan==
2CL8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CA and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CL8 OCA].
<StructureSection load='2cl8' size='340' side='right'caption='[[2cl8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
[[Category: Mus musculus]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CL8 FirstGlance]. <br>
[[Category: Brown, G.D.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Brown, J.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
[[Category: Callaghan, C.A.O.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cl8 OCA], [https://pdbe.org/2cl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cl8 ProSAT]</span></td></tr>
[[Category: Gilbert, R.J.C.]]
</table>
[[Category: Gordon, S.]]
== Evolutionary Conservation ==
[[Category: Jones, E.Y.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Marshall, A.S.J.]]
Check<jmol>
[[Category: Siebold, C.]]
  <jmolCheckbox>
[[Category: CA]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2cl8_consurf.spt"</scriptWhenChecked>
[[Category: CL]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: beta-glucan]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: c-type lectin-like domain]]
  </jmolCheckbox>
[[Category: carbohydrate]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cl8 ConSurf].
[[Category: ctld]]
<div style="clear:both"></div>
[[Category: dectin-1]]
<div style="background-color:#fffaf0;">
[[Category: fungal recognition]]
== Publication Abstract from PubMed ==
[[Category: laminarin]]
The murine molecule dectin-1 (known as the beta-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal beta-glucans. We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 angstroms resolution structure in which a short soaked natural beta-glucan is trapped in the crystal lattice. In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and beta-glucans. These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens.
[[Category: receptor]]


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 13:52:22 2007''
Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.,Brown J, O'Callaghan CA, Marshall AS, Gilbert RJ, Siebold C, Gordon S, Brown GD, Jones EY Protein Sci. 2007 Jun;16(6):1042-52. Epub 2007 May 1. PMID:17473009<ref>PMID:17473009</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2cl8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Brown GD]]
[[Category: Brown J]]
[[Category: Gilbert RJC]]
[[Category: Gordon S]]
[[Category: Jones EY]]
[[Category: Marshall ASJ]]
[[Category: O'Callaghan CA]]
[[Category: Siebold C]]
Retrieved from "https://proteopedia.org/2cl8"