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[[Image:2htm.jpg|left|200px]]


{{Structure
==Crystal structure of TTHA0676 from Thermus thermophilus HB8==
|PDB= 2htm |SIZE=350|CAPTION= <scene name='initialview01'>2htm</scene>, resolution 2.30&Aring;
<StructureSection load='2htm' size='340' side='right'caption='[[2htm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2htm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HTM FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htm OCA], [https://pdbe.org/2htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2htm RCSB], [https://www.ebi.ac.uk/pdbsum/2htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2htm ProSAT], [https://www.topsan.org/Proteins/RSGI/2htm TOPSAN]</span></td></tr>
 
</table>
'''Crystal structure of TTHA0676 from Thermus thermophilus HB8'''
== Function ==
 
[https://www.uniprot.org/uniprot/THIG_THET8 THIG_THET8] Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity).
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2HTM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTM OCA].  
Check<jmol>
[[Category: Protein complex]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/2htm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2htm ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Kunishima, N.]]
[[Category: Kunishima N]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sugahara M]]
[[Category: Sugahara, M.]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: thermus thermophilus hb8]]
[[Category: thiamin biosynthesis]]
[[Category: thig]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:21:24 2008''

Latest revision as of 08:09, 30 October 2024

Crystal structure of TTHA0676 from Thermus thermophilus HB8

2htm, resolution 2.30Å

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