2hw5: Difference between revisions

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[[Image:2hw5.gif|left|200px]]


{{Structure
==The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1==
|PDB= 2hw5 |SIZE=350|CAPTION= <scene name='initialview01'>2hw5</scene>, resolution 2.55&Aring;
<StructureSection load='2hw5' size='340' side='right'caption='[[2hw5]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=COO:CROTONYL COENZYME A'>COO</scene>
<table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HW5 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
|GENE= ECHS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw5 OCA], [https://pdbe.org/2hw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hw5 RCSB], [https://www.ebi.ac.uk/pdbsum/2hw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hw5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ECHM_HUMAN ECHM_HUMAN] Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/2hw5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hw5 ConSurf].
<div style="clear:both"></div>


'''The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1'''
==See Also==
 
*[[Enoyl-CoA hydratase 3D structures|Enoyl-CoA hydratase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2HW5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA].
[[Category: Enoyl-CoA hydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Debreczeni, J.]]
[[Category: Debreczeni J]]
[[Category: Delft, F von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Gorrec F]]
[[Category: Gorrec, F.]]
[[Category: Kavanagh K]]
[[Category: Kavanagh, K.]]
[[Category: Niesen F]]
[[Category: Niesen, F.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W.]]
[[Category: Salah E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Salah, E.]]
[[Category: Turnbull AP]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu E]]
[[Category: Turnbull, A P.]]
[[Category: Umeano C]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt J]]
[[Category: Umeano, C.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: COO]]
[[Category: MG]]
[[Category: beta-oxidation]]
[[Category: coa]]
[[Category: enoyl-coa hydratase]]
[[Category: fatty acid metabolism]]
[[Category: hydratase/isomerase superfamily]]
[[Category: lyase]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:22:20 2008''
Retrieved from "https://proteopedia.org/2hw5"