2i5e: Difference between revisions

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[[Image:2i5e.gif|left|200px]]


{{Structure
==Crystal Structure of a Protein of Unknown Function MM2497 from Methanosarcina mazei Go1, Probable Nucleotidyltransferase==
|PDB= 2i5e |SIZE=350|CAPTION= <scene name='initialview01'>2i5e</scene>, resolution 2.10&Aring;
<StructureSection load='2i5e' size='340' side='right'caption='[[2i5e]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
<table><tr><td colspan='2'>[[2i5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei_Go1 Methanosarcina mazei Go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I5E FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= Methanosarcina mazei ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2209 Methanosarcina mazei])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i5e OCA], [https://pdbe.org/2i5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i5e RCSB], [https://www.ebi.ac.uk/pdbsum/2i5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i5e ProSAT], [https://www.topsan.org/Proteins/MCSG/2i5e TOPSAN]</span></td></tr>
 
</table>
'''Crystal Structure of a Protein of Unknown Function MM2497 from Methanosarcina mazei Go1, Probable Nucleotidyltransferase'''
== Function ==
 
[https://www.uniprot.org/uniprot/COFC_METMA COFC_METMA] Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.[HAMAP-Rule:MF_02114]
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2I5E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei Methanosarcina mazei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I5E OCA].
Check<jmol>
[[Category: Methanosarcina mazei]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/2i5e_consurf.spt"</scriptWhenChecked>
[[Category: Clancy, S.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Du, J.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Joachimiak, A.]]
  </jmolCheckbox>
[[Category: MCSG, Midwest Center for Structural Genomics.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i5e ConSurf].
[[Category: Tan, K.]]
<div style="clear:both"></div>
[[Category: PEG]]
__TOC__
[[Category: TRS]]
</StructureSection>
[[Category: apc86122]]
[[Category: Large Structures]]
[[Category: hypothetic protein]]
[[Category: Methanosarcina mazei Go1]]
[[Category: mcsg]]
[[Category: Clancy S]]
[[Category: methanosarcina mazei go1]]
[[Category: Du J]]
[[Category: midwest center for structural genomic]]
[[Category: Joachimiak A]]
[[Category: protein structure initiative]]
[[Category: Tan K]]
[[Category: psi-2]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:25:38 2008''

Latest revision as of 08:10, 30 October 2024

Crystal Structure of a Protein of Unknown Function MM2497 from Methanosarcina mazei Go1, Probable Nucleotidyltransferase

2i5e, resolution 2.10Å

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