2j66: Difference between revisions

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New page: left|200px<br /> <applet load="2j66" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j66, resolution 1.65Å" /> '''STRUCTURAL CHARACTE...
 
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[[Image:2j66.gif|left|200px]]<br />
<applet load="2j66" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2j66, resolution 1.65&Aring;" />
'''STRUCTURAL CHARACTERISATION OF BTRK DECARBOXYLASE FROM BUTIROSIN BIOSYNTHESIS'''<br />


==About this Structure==
==Structural characterisation of BtrK decarboxylase from butirosin biosynthesis==
2J66 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]] with EDO and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J66 OCA]].  
<StructureSection load='2j66' size='340' side='right'caption='[[2j66]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
[[Category: Bacillus circulans]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2j66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Niallia_circulans Niallia circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J66 FirstGlance]. <br>
[[Category: Blundell, T.L.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
[[Category: Chirgadze, D.Y.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
[[Category: Li, Y.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j66 OCA], [https://pdbe.org/2j66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j66 RCSB], [https://www.ebi.ac.uk/pdbsum/2j66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j66 ProSAT]</span></td></tr>
[[Category: Popovic, B.]]
</table>
[[Category: Spencer, J.B.]]
== Function ==
[[Category: EDO]]
[https://www.uniprot.org/uniprot/BTRK_NIACI BTRK_NIACI] Pyridoxal phosphate-dependent decarboxylase that catalyzes 1 step in the biosynthesis of the side chain of the aminoglycoside antibiotics in the biosynthetic pathway of butirosin. Able to decarboxylate L-ornithine, L-arginine, L-lysine, but not L-glutamate or any D-amino acids. Has low activity with substrates not bound to an acyl-carrier protein.<ref>PMID:15975512</ref>
[[Category: PLP]]
== Evolutionary Conservation ==
[[Category: ahba biosynthesis]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: butirosin]]
Check<jmol>
[[Category: decarboxylase]]
  <jmolCheckbox>
[[Category: lyase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j66_consurf.spt"</scriptWhenChecked>
 
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 16:59:06 2007''
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j66 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Niallia circulans]]
[[Category: Blundell TL]]
[[Category: Chirgadze DY]]
[[Category: Li Y]]
[[Category: Popovic B]]
[[Category: Spencer JB]]
Retrieved from "https://proteopedia.org/2j66"