2iip: Difference between revisions

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[[Image:2iip.gif|left|200px]]


{{Structure
==Human Nicotinamide N-methyltransferase==
|PDB= 2iip |SIZE=350|CAPTION= <scene name='initialview01'>2iip</scene>, resolution 2.05&Aring;
<StructureSection load='2iip' size='340' side='right'caption='[[2iip]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
<table><tr><td colspan='2'>[[2iip]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IIP FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Nicotinamide_N-methyltransferase Nicotinamide N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.1 2.1.1.1]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
|GENE= NNMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iip OCA], [https://pdbe.org/2iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iip RCSB], [https://www.ebi.ac.uk/pdbsum/2iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iip ProSAT]</span></td></tr>
 
</table>
'''Human Nicotinamide N-methyltransferase'''
== Function ==
 
[https://www.uniprot.org/uniprot/NNMT_HUMAN NNMT_HUMAN] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
 
== Evolutionary Conservation ==
==Disease==
[[Image:Consurf_key_small.gif|200px|right]]
Known disease associated with this structure: Homocysteine plasma level OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600008 600008]]
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2iip_consurf.spt"</scriptWhenChecked>
2IIP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIP OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iip ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nicotinamide N-methyltransferase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Avvakumov GV]]
[[Category: Avvakumov, G V.]]
[[Category: Bernstein G]]
[[Category: Bernstein, G.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Loppnau P]]
[[Category: Loppnau, P.]]
[[Category: Min J]]
[[Category: Min, J.]]
[[Category: Plotnikov AN]]
[[Category: Plotnikov, A N.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Tempel W]]
[[Category: Sundstrom, M.]]
[[Category: Wasney G]]
[[Category: Tempel, W.]]
[[Category: Weigelt J]]
[[Category: Wasney, G.]]
[[Category: Wu H]]
[[Category: Weigelt, J.]]
[[Category: Zeng H]]
[[Category: Wu, H.]]
[[Category: Zeng, H.]]
[[Category: SAH]]
[[Category: methyltransferase]]
[[Category: mutant]]
[[Category: mutation]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: surface mutagenesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:30:04 2008''
Retrieved from "https://proteopedia.org/2iip"