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[[Image:2itb.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF A PUTATIVE TRNA-(MS(2)IO(6)A)-HYDROXYLASE (PP_2188) FROM PSEUDOMONAS PUTIDA KT2440 AT 2.05 A RESOLUTION==
|PDB= 2itb |SIZE=350|CAPTION= <scene name='initialview01'>2itb</scene>, resolution 2.050&Aring;
<StructureSection load='2itb' size='340' side='right'caption='[[2itb]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>, <scene name='pdbligand=UNL:'>UNL</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
<table><tr><td colspan='2'>[[2itb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida_KT2440 Pseudomonas putida KT2440]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ITB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ITB FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
|GENE= NP_744337.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=303 Pseudomonas putida])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2itb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2itb OCA], [https://pdbe.org/2itb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2itb RCSB], [https://www.ebi.ac.uk/pdbsum/2itb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2itb ProSAT], [https://www.topsan.org/Proteins/JCSG/2itb TOPSAN]</span></td></tr>
 
</table>
'''Crystal structure of putative tRNA-(ms(2)io(6)a)-hydroxylase (NP_744337.1) from Pseudomonas Putida KT2440 at 2.05 A resolution'''
== Function ==
 
[https://www.uniprot.org/uniprot/MIAE_PSEPK MIAE_PSEPK] Involved in specific tRNA modification. Catalyzes the oxygen-dependent hydroxylation of 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) to produce 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A) at position 37 in tRNAs.<ref>PMID:32785618</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2ITB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ITB OCA].
Check<jmol>
[[Category: Pseudomonas putida]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/2itb_consurf.spt"</scriptWhenChecked>
[[Category: JCSG, Joint Center for Structural Genomics.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: EDO]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: FE]]
  </jmolCheckbox>
[[Category: PER]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2itb ConSurf].
[[Category: UNL]]
<div style="clear:both"></div>
[[Category: jcsg]]
== References ==
[[Category: joint center for structural genomic]]
<references/>
[[Category: np_744337 1]]
__TOC__
[[Category: protein structure initiative]]
</StructureSection>
[[Category: psi-2]]
[[Category: Large Structures]]
[[Category: putative trna-(ms(2)io(6)a)-hydroxylase]]
[[Category: Pseudomonas putida KT2440]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:33:04 2008''

Latest revision as of 07:40, 9 October 2024

CRYSTAL STRUCTURE OF A PUTATIVE TRNA-(MS(2)IO(6)A)-HYDROXYLASE (PP_2188) FROM PSEUDOMONAS PUTIDA KT2440 AT 2.05 A RESOLUTION

2itb, resolution 2.05Å

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