2j7k: Difference between revisions

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[[Image:2j7k.jpg|left|200px]]


{{Structure
==Crystal structure of the T84A mutant EF-G:GDPCP complex==
|PDB= 2j7k |SIZE=350|CAPTION= <scene name='initialview01'>2j7k</scene>, resolution 2.90&Aring;
<StructureSection load='2j7k' size='340' side='right'caption='[[2j7k]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+A'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER'>GCP</scene>
<table><tr><td colspan='2'>[[2j7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7K FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-synthesizing_GTPase Protein-synthesizing GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.3 3.6.5.3]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7k OCA], [https://pdbe.org/2j7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7k RCSB], [https://www.ebi.ac.uk/pdbsum/2j7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EFG_THETH EFG_THETH] Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j7k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j7k ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF THE T84A MUTANT EF-G:GDPCP COMPLEX'''
==See Also==
 
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2J7K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7K OCA].
[[Category: Large Structures]]
[[Category: Protein-synthesizing GTPase]]
[[Category: Thermus thermophilus HB8]]
[[Category: Single protein]]
[[Category: Hansson S]]
[[Category: Thermus thermophilus]]
[[Category: Logan DT]]
[[Category: Hansson, S.]]
[[Category: Logan, D T.]]
[[Category: GCP]]
[[Category: MG]]
[[Category: elongation factor]]
[[Category: gtp-binding]]
[[Category: mutation]]
[[Category: nucleotide- binding]]
[[Category: nucleotide-binding]]
[[Category: p-loop]]
[[Category: protein biosynthesis]]
[[Category: thr84ala]]
[[Category: translation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:38:17 2008''
Retrieved from "https://proteopedia.org/2j7k"