4xj6: Difference between revisions
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New page: '''Unreleased structure''' The entry 4xj6 is ON HOLD Authors: Kato, K., Ishii, R., Ishitani, R., Nureki, O. Description: Category: Unreleased Structures Category: Nureki, O [[... |
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==Crystal structure of Escherichia coli DncV 3'-deoxy GTP bound form== | |||
<StructureSection load='4xj6' size='340' side='right'caption='[[4xj6]], [[Resolution|resolution]] 2.31Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xj6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJ6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GH3:3-DEOXY-GUANOSINE-5-TRIPHOSPHATE'>GH3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xj6 OCA], [https://pdbe.org/4xj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xj6 RCSB], [https://www.ebi.ac.uk/pdbsum/4xj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xj6 ProSAT]</span></td></tr> | ||
[[Category: Ishii | </table> | ||
[[Category: Ishitani | == Function == | ||
[[Category: Kato | [https://www.uniprot.org/uniprot/DNCV1_ECOLX DNCV1_ECOLX] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-C(GA) CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> Catalyzes the synthesis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP) from GTP and ATP, a second messenger in cell signal transduction. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, 3'3'-cGAMP is the dominant molecule produced by DncV in vivo, contrary to the 2'3'-cGAMP produced by eukaryotes. By producing cGAMP, down-regulates csgD expression and expression of flagellum regulon genes, which leads to the down-regulation of rdar biofilm formation and flagellum-mediated swimming and swarming motility in a temperature-dependent manner (PubMed:30837338). Controls the activity of cGAMP-activated phospholipase CapV, a patatin-like lipase that is a direct 3',3'-cGAMP receptor encoded in the dncV operon (By similarity).[UniProtKB:Q9KVG7]<ref>PMID:30837338</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Large Structures]] | |||
[[Category: Ishii R]] | |||
[[Category: Ishitani R]] | |||
[[Category: Kato K]] | |||
[[Category: Nureki O]] | |||
Latest revision as of 09:02, 20 March 2024
Crystal structure of Escherichia coli DncV 3'-deoxy GTP bound form
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