2k1b: Difference between revisions
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==Solution NMR structure of the chromo domain of the chromobox protein homolog 7== | |||
<StructureSection load='2k1b' size='340' side='right'caption='[[2k1b]]' scene=''> | |||
| | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1B FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1b OCA], [https://pdbe.org/2k1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1b RCSB], [https://www.ebi.ac.uk/pdbsum/2k1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
''' | [https://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> | ||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
== | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/2k1b_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k1b ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Fares | [[Category: Fares C]] | ||
[[Category: Gutmanas | [[Category: Gutmanas A]] | ||
[[Category: Kaustov | [[Category: Kaustov L]] | ||
[[Category: Lemak | [[Category: Lemak A]] | ||
[[Category: Loppnau | [[Category: Loppnau P]] | ||
[[Category: Min | [[Category: Min J]] | ||
[[Category: Quyang | [[Category: Quyang H]] | ||
[[Category: Ravichandran | [[Category: Ravichandran M]] | ||
[[Category: Weigelt J]] | |||
[[Category: Weigelt | |||
Latest revision as of 09:43, 9 May 2024
Solution NMR structure of the chromo domain of the chromobox protein homolog 7
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