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==Fuc_TBA==
==Fuc_TBA==
<StructureSection load='2lyg' size='340' side='right' caption='[[2lyg]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
<StructureSection load='2lyg' size='340' side='right'caption='[[2lyg]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LYG FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LYG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CF:2-HYDROXYETHYL+6-DEOXY-BETA-L-GALACTOPYRANOSIDE'>1CF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [http://www.ebi.ac.uk/pdbsum/2lyg PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CF:2-HYDROXYETHYL+6-DEOXY-BETA-L-GALACTOPYRANOSIDE'>1CF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [https://pdbe.org/2lyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [https://www.ebi.ac.uk/pdbsum/2lyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyg ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5'-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands.
Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end.,Gomez-Pinto I, Vengut-Climent E, Lucas R, Avino A, Eritja R, Gonzalez C, Morales JC Chemistry. 2013 Feb 4;19(6):1920-7. doi: 10.1002/chem.201203902. Epub 2013 Jan, 11. PMID:23315826<ref>PMID:23315826</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Avio, A]]
[[Category: Large Structures]]
[[Category: Eritja, R]]
[[Category: Avio A]]
[[Category: Gomez-Pinto, I]]
[[Category: Eritja R]]
[[Category: Gonzalez-Ibaez, C]]
[[Category: Gomez-Pinto I]]
[[Category: Lucas, R]]
[[Category: Gonzalez-Ibaez C]]
[[Category: Morales, J]]
[[Category: Lucas R]]
[[Category: Vengut-Climent, E]]
[[Category: Morales J]]
[[Category: Carbohydrate-dna interaction]]
[[Category: Vengut-Climent E]]
[[Category: Dna]]
[[Category: G-quadruplex structure]]
Retrieved from "https://proteopedia.org/2lyg"