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[[Image:2npt.gif|left|200px]]


{{Structure
==Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)==
|PDB= 2npt |SIZE=350|CAPTION= <scene name='initialview01'>2npt</scene>, resolution 1.75&Aring;
<StructureSection load='2npt' size='340' side='right'caption='[[2npt]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2npt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPT FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
|GENE= MAP2K5, MEK5, MKK5, PRKMK5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), MAP3K2, MAPKKK2, MEKK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npt OCA], [https://pdbe.org/2npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npt RCSB], [https://www.ebi.ac.uk/pdbsum/2npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npt ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/2npt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2npt ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)'''
==See Also==
 
*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
 
*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
==About this Structure==
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
2NPT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA].
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase kinase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Debreczeni J]]
[[Category: Debreczeni, J.]]
[[Category: Edwards A]]
[[Category: Delft, F von.]]
[[Category: Filippakopoulos P]]
[[Category: Edwards, A.]]
[[Category: Knapp S]]
[[Category: Filippakopoulos, P.]]
[[Category: Papagrigoriou V]]
[[Category: Knapp, S.]]
[[Category: Sundstrom M]]
[[Category: Papagrigoriou, V.]]
[[Category: Turnbull A]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Von Delft F]]
[[Category: Sundstrom, M.]]
[[Category: Turnbull, A.]]
[[Category: map kinase kinase 5]]
[[Category: map2k5]]
[[Category: map3k2]]
[[Category: mapk/erk kinase kinase 2]]
[[Category: mapkkk2]]
[[Category: mek kinase 2]]
[[Category: mek5]]
[[Category: mekk2]]
[[Category: mekk2b]]
[[Category: mitogen activated protein kinase kinase 5]]
[[Category: mitogen activated protein kinase kinase kinase 2]]
[[Category: mkk5]]
[[Category: phox]]
[[Category: phox-domain]]
[[Category: prkmk5]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:49:29 2008''
Retrieved from "https://proteopedia.org/2npt"