1qji: Difference between revisions
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== | ==Structure of astacin with a transition-state analogue inhibitor== | ||
<StructureSection load='1qji' size='340' side='right'caption='[[1qji]], [[Resolution|resolution]] 2.14Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1qji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QJI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PKF:CARBOBENZOXY-PRO-LYS-PHE-Y(PO2)-ALA-PRO-OME'>PKF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qji OCA], [https://pdbe.org/1qji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qji RCSB], [https://www.ebi.ac.uk/pdbsum/1qji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qji ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ASTA_ASTAS ASTA_ASTAS] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/1qji_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qji ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Proteinase 3D structures|Proteinase 3D structures]] | |||
[[ | __TOC__ | ||
</StructureSection> | |||
[[Category: Astacus astacus]] | [[Category: Astacus astacus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bode | [[Category: Bode W]] | ||
[[Category: Grams | [[Category: Grams F]] | ||
[[Category: Stocker | [[Category: Stocker W]] | ||
Latest revision as of 04:50, 17 October 2024
Structure of astacin with a transition-state analogue inhibitor
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