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==Crystal structure of uricase from Arthrobacter globiformis in complex with 8-azaxanthin (inhibitor)==
==Crystal structure of uricase from Arthrobacter globiformis in complex with 8-azaxanthin (inhibitor)==
<StructureSection load='2yzd' size='340' side='right' caption='[[2yzd]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
<StructureSection load='2yzd' size='340' side='right'caption='[[2yzd]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yzd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YZD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yzd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YZD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vay|1vay]], [[1vax|1vax]], [[1uox|1uox]], [[2yzb|2yzb]], [[2yzc|2yzc]], [[2yze|2yze]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yzd OCA], [https://pdbe.org/2yzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yzd RCSB], [https://www.ebi.ac.uk/pdbsum/2yzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yzd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yzd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yzd RCSB], [http://www.ebi.ac.uk/pdbsum/2yzd PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/URIC_ARTGO URIC_ARTGO]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yzd_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yzd_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yzd ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Urate Oxidase|Urate Oxidase]]
*[[Urate oxidase 3D structures|Urate oxidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arthrobacter globiformis]]
[[Category: Arthrobacter globiformis]]
[[Category: Urate oxidase]]
[[Category: Large Structures]]
[[Category: Hoque, M M]]
[[Category: Hoque MM]]
[[Category: Hossain, M T]]
[[Category: Hossain MT]]
[[Category: Juan, E C.M]]
[[Category: Juan ECM]]
[[Category: Sekiguchi, T]]
[[Category: Sekiguchi T]]
[[Category: Suzuki, K]]
[[Category: Suzuki K]]
[[Category: Takenaka, A]]
[[Category: Takenaka A]]
[[Category: 8-azaxanthin]]
[[Category: Oxidoreductase]]
[[Category: Uricase]]

Latest revision as of 05:55, 6 August 2025

Crystal structure of uricase from Arthrobacter globiformis in complex with 8-azaxanthin (inhibitor)

2yzd, resolution 2.24Å

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