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==Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121==
==Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121==
<StructureSection load='4ips' size='340' side='right' caption='[[4ips]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='4ips' size='340' side='right'caption='[[4ips]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ips]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IPS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ips]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IPS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1G4:(3S,6S)-3,6-BIS(4-HYDROXYBENZYL)PIPERAZIN-2-ONE'>1G4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ict|4ict]], [[4ipw|4ipw]], [[4iq7|4iq7]], [[4iq9|4iq9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1G4:(3S,6S)-3,6-BIS(4-HYDROXYBENZYL)PIPERAZIN-2-ONE'>1G4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cyp121, Rv2276, MT2336, MTCY339.34c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ips FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ips OCA], [https://pdbe.org/4ips PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ips RCSB], [https://www.ebi.ac.uk/pdbsum/4ips PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ips ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ips FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ips OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ips RCSB], [http://www.ebi.ac.uk/pdbsum/4ips PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CP121_MYCTU CP121_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4ips" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Cytochrome P450|Cytochrome P450]]
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Belin, P]]
[[Category: Belin P]]
[[Category: Dubois, S]]
[[Category: Dubois S]]
[[Category: Fonvielle, M]]
[[Category: Fonvielle M]]
[[Category: Gondry, M]]
[[Category: Gondry M]]
[[Category: Grach, G]]
[[Category: Grach G]]
[[Category: Jacquet, M]]
[[Category: Jacquet M]]
[[Category: LeDu, M H]]
[[Category: LeDu MH]]
[[Category: Lecoq, A]]
[[Category: Lecoq A]]
[[Category: Lequin, O]]
[[Category: Lequin O]]
[[Category: Thai, R]]
[[Category: Thai R]]
[[Category: Cyclo-dipeptide]]
[[Category: Oxidoreductase]]
[[Category: Oxydase]]
[[Category: P450 fold]]
[[Category: Protein-ligand complex]]
Retrieved from "https://proteopedia.org/4ips"