1gzt: Difference between revisions

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New page: left|200px<br /> <applet load="1gzt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gzt, resolution 1.30Å" /> '''PSEUDOMONAS AERUGIN...
 
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[[Image:1gzt.gif|left|200px]]<br />
<applet load="1gzt" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1gzt, resolution 1.30&Aring;" />
'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''<br />


==Overview==
==Pseudomonas aeruginosa lectin II (PA-IIL) together with fucose==
Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and, PA-IIL) contribute to the virulence of this pathogenic bacterium, which is, a major cause of morbidity and mortality in cystic fibrosis patients. The, crystal structure of PA-IIL in complex with fucose reveals a tetrameric, structure. Each monomer displays a nine-stranded, antiparallel b-sandwich, arrangement and contains two close calcium cations that mediate the, binding of fucose in a recognition mode unique among carbohydrate-protein, interactions. Experimental binding studies, together with theoretical, docking of fucose-containing oligosaccharides, are consistent with the, assumption that antigens of the Lewis a (Le(a)) series may be the, preferred ligands of this lectin. Precise knowledge of the ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12415289 (full description)]]
<StructureSection load='1gzt' size='340' side='right'caption='[[1gzt]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1gzt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZT FirstGlance]. <br>
1GZT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with FUC and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzt OCA], [https://pdbe.org/1gzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzt RCSB], [https://www.ebi.ac.uk/pdbsum/1gzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzt ProSAT]</span></td></tr>
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12415289 12415289]
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9HYN5_PSEAE Q9HYN5_PSEAE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gzt ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Gilboa-Garber N]]
[[Category: Gilboa-Garber, N.]]
[[Category: Imberty A]]
[[Category: Imberty, A.]]
[[Category: Mitchell E]]
[[Category: Mitchell, E.]]
[[Category: CA]]
[[Category: FUC]]
[[Category: fucose]]
[[Category: lectin]]
[[Category: sugar-binding protein]]
 
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