2olm: Difference between revisions

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[[Image:2olm.gif|left|200px]]


{{Structure
==ArfGap domain of HIV-1 Rev binding protein==
|PDB= 2olm |SIZE=350|CAPTION= <scene name='initialview01'>2olm</scene>, resolution 1.480&Aring;
<StructureSection load='2olm' size='340' side='right'caption='[[2olm]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNL:'>UNL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
<table><tr><td colspan='2'>[[2olm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OLM FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
|GENE= HRB, RAB, RIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2olm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2olm OCA], [https://pdbe.org/2olm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2olm RCSB], [https://www.ebi.ac.uk/pdbsum/2olm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2olm ProSAT]</span></td></tr>
 
</table>
'''ArfGap domain of HIV-1 Rev binding protein'''
== Function ==
 
[https://www.uniprot.org/uniprot/AGFG1_HUMAN AGFG1_HUMAN] Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.<ref>PMID:10613896</ref> <ref>PMID:14701878</ref> <ref>PMID:15749819</ref>
 
== Evolutionary Conservation ==
==Disease==
[[Image:Consurf_key_small.gif|200px|right]]
Known disease associated with this structure: Carpenter syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606144 606144]]
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ol/2olm_consurf.spt"</scriptWhenChecked>
2OLM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OLM OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2olm ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Dimov, S.]]
[[Category: Dimov S]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Landry, R.]]
[[Category: Landry R]]
[[Category: Park, H.]]
[[Category: Park H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Shen L]]
[[Category: Shen, L.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Tong Y]]
[[Category: Tong, Y.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: GOL]]
[[Category: SO4]]
[[Category: UNL]]
[[Category: UNX]]
[[Category: ZN]]
[[Category: aid]]
[[Category: arfgap]]
[[Category: gtpase-activating protein]]
[[Category: hiv]]
[[Category: human immunodeficiency virus]]
[[Category: nucleoporin]]
[[Category: rev-interacting protein]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:01:19 2008''
Retrieved from "https://proteopedia.org/2olm"