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==Crystal structure of M. tuberculosis KasA in complex with TLM5==
==Crystal structure of M. tuberculosis KasA in complex with TLM5==
<StructureSection load='4c6u' size='340' side='right' caption='[[4c6u]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4c6u' size='340' side='right'caption='[[4c6u]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c6u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_sp._h37rv Mycobacterium sp. h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C6U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C6U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TLG:(5R)-3-ACETYL-4-HYDROXY-5-METHYL-5-[(1Z)-2-METHYLBUTA-1,3-DIEN-1-YL]THIOPHEN-2(5H)-ONE'>TLG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c6v|4c6v]], [[4c6w|4c6w]], [[4c6x|4c6x]], [[4c6z|4c6z]], [[4c70|4c70]], [[4c71|4c71]], [[4c72|4c72]], [[4c73|4c73]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TLG:(5R)-3-ACETYL-4-HYDROXY-5-METHYL-5-[(1Z)-2-METHYLBUTA-1,3-DIEN-1-YL]THIOPHEN-2(5H)-ONE'>TLG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6u OCA], [https://pdbe.org/4c6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c6u RCSB], [https://www.ebi.ac.uk/pdbsum/4c6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c6u RCSB], [http://www.ebi.ac.uk/pdbsum/4c6u PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4c6u" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Acyl carrier protein synthase|Acyl carrier protein synthase]]
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycobacterium sp. h37rv]]
[[Category: Large Structures]]
[[Category: Bommineni, G R]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Fekete, A]]
[[Category: Bommineni GR]]
[[Category: Kapilashrami, K]]
[[Category: Fekete A]]
[[Category: Kisker, C]]
[[Category: Kapilashrami K]]
[[Category: Mueller, M J]]
[[Category: Kisker C]]
[[Category: Schaefer, C M]]
[[Category: Mueller MJ]]
[[Category: Schiebel, J]]
[[Category: Schaefer CM]]
[[Category: Tonge, P J]]
[[Category: Schiebel J]]
[[Category: Kas enzyme]]
[[Category: Tonge PJ]]
[[Category: Mycolic acid synthesis]]
[[Category: Thiolactomycin]]
[[Category: Transferase]]
[[Category: Type 2 fatty acid biosynthesis]]

Latest revision as of 12:05, 20 December 2023

Crystal structure of M. tuberculosis KasA in complex with TLM5

4c6u, resolution 2.40Å

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