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==Dbr1 in complex with guanosine-5'-monophosphate==
==Dbr1 in complex with guanosine-5'-monophosphate==
<StructureSection load='4peg' size='340' side='right' caption='[[4peg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4peg' size='340' side='right'caption='[[4peg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4peg]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PEG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4peg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PEG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pef|4pef]], [[4peh|4peh]], [[4pei|4pei]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4peg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4peg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4peg RCSB], [http://www.ebi.ac.uk/pdbsum/4peg PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4peg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4peg OCA], [https://pdbe.org/4peg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4peg RCSB], [https://www.ebi.ac.uk/pdbsum/4peg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4peg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DBR1_ENTH1 DBR1_ENTH1] Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover.<ref>PMID:25123664</ref> <ref>PMID:27930312</ref> <ref>PMID:28504306</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4peg" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clark, N E]]
[[Category: Entamoeba histolytica]]
[[Category: Combs, D J]]
[[Category: Large Structures]]
[[Category: Damha, M J]]
[[Category: Clark NE]]
[[Category: Hart, P J]]
[[Category: Combs DJ]]
[[Category: Holloway, S P]]
[[Category: Damha MJ]]
[[Category: Johnsson, R]]
[[Category: Hart PJ]]
[[Category: Katolik, A]]
[[Category: Holloway SP]]
[[Category: Montemayor, E J]]
[[Category: Johnsson R]]
[[Category: Schuermann, J P]]
[[Category: Katolik A]]
[[Category: Stevens, S W]]
[[Category: Montemayor EJ]]
[[Category: Taylor, A B]]
[[Category: Schuermann JP]]
[[Category: Hydrolase]]
[[Category: Stevens SW]]
[[Category: Lariat rna]]
[[Category: Taylor AB]]
[[Category: Metalloenzyme]]
[[Category: Metallohydrolase]]
[[Category: Metallophosphoesterase]]
[[Category: Nuclease]]
[[Category: Phosphodiesterase]]
Retrieved from "https://proteopedia.org/4peg"