4s0h: Difference between revisions

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'''Unreleased structure'''


The entry 4s0h is ON HOLD
==TBX5 DB, NKX2.5 HD, ANF DNA Complex==
<StructureSection load='4s0h' size='340' side='right'caption='[[4s0h]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4s0h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.817&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0h OCA], [https://pdbe.org/4s0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0h RCSB], [https://www.ebi.ac.uk/pdbsum/4s0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0h ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] Holt-Oram syndrome. The disease is caused by mutations affecting the gene represented in this entry.  Defects in TBX5 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref>
== Function ==
[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> <ref>PMID:8988164</ref>


Authors: Pradhan, L.
==See Also==
 
*[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]]
Description: TBX5 DB, NKX2.5 HD, ANF DNA Complex
*[[T-box proteins|T-box proteins]]
[[Category: Unreleased Structures]]
== References ==
[[Category: Pradhan, L]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Pradhan L]]
Retrieved from "https://proteopedia.org/4s0h"