4x8p: Difference between revisions

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'''Unreleased structure'''


The entry 4x8p is ON HOLD  until Paper Publication
==Crystal structure of Ash2L SPRY domain in complex with RbBP5==
<StructureSection load='4x8p' size='340' side='right'caption='[[4x8p]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4x8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X8P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x8p OCA], [https://pdbe.org/4x8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x8p RCSB], [https://www.ebi.ac.uk/pdbsum/4x8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x8p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref>


Authors: Zhang, P., Chaturvedi, C.P., Brunzelle, J.S., Skiniotis, G., Brand, M., Shilatifard, A., Couture, J.-F.
==See Also==
 
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
Description: Crystal structure of Ash2L SPRY domain in complex with RbBP5
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Brand, M]]
__TOC__
[[Category: Couture, J.-F]]
</StructureSection>
[[Category: Shilatifard, A]]
[[Category: Homo sapiens]]
[[Category: Skiniotis, G]]
[[Category: Large Structures]]
[[Category: Chaturvedi, C.P]]
[[Category: Brand M]]
[[Category: Zhang, P]]
[[Category: Brunzelle JS]]
[[Category: Brunzelle, J.S]]
[[Category: Chaturvedi CP]]
[[Category: Couture J-F]]
[[Category: Shilatifard A]]
[[Category: Skiniotis G]]
[[Category: Zhang P]]
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