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==Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galp==
==Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galp==
<StructureSection load='4rpl' size='340' side='right' caption='[[4rpl]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='4rpl' size='340' side='right'caption='[[4rpl]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rpl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RPL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rpl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RPL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UC:[(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+(2R,5S,6R)-3,3,4,4-TETRAFLUORO-5-HYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL+DIHYDROGEN+DIPHOSPHATE+(NON-PREFERRED+NAME)'>3UC</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2499&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1voj|1voj]], [[4rpg|4rpg]], [[4rph|4rph]], [[4rpj|4rpj]], [[4rpk|4rpk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UC:[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl+(2R,5S,6R)-3,3,4,4-tetrafluoro-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl+dihydrogen+diphosphate+(non-preferred+name)'>3UC</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rpl OCA], [https://pdbe.org/4rpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rpl RCSB], [https://www.ebi.ac.uk/pdbsum/4rpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rpl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rpl RCSB], [http://www.ebi.ac.uk/pdbsum/4rpl PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLF_MYCTU GLF_MYCTU]] Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) which is a key building block for cell wall construction in Mycobacterium tuberculosis.<ref>PMID:9692181</ref>
[https://www.uniprot.org/uniprot/GLF_MYCTU GLF_MYCTU] Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) which is a key building block for cell wall construction in Mycobacterium tuberculosis.<ref>PMID:9692181</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4rpl" style="background-color:#fffaf0;"></div>
==See Also==
*[[UDP-galactopyranose mutase 3D structures|UDP-galactopyranose mutase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: UDP-galactopyranose mutase]]
[[Category: Large Structures]]
[[Category: Sanders, D A.R]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Straaten, K E.Van]]
[[Category: Sanders DAR]]
[[Category: Fad]]
[[Category: Van Straaten KE]]
[[Category: Flavoenzyme]]
[[Category: Isomerase]]
[[Category: Mtugm]]
[[Category: Udp-galactopyranose mutase]]
Retrieved from "https://proteopedia.org/4rpl"