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==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
<StructureSection load='4uxs' size='340' side='right' caption='[[4uxs]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
<SX load='4uxs' size='340' side='right' viewer='molstar' caption='[[4uxs]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4uxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UXS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uxo|4uxo]], [[4uxp|4uxp]], [[4uxr|4uxr]], [[4uxt|4uxt]], [[4uxy|4uxy]], [[4uy0|4uy0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [http://www.ebi.ac.uk/pdbsum/4uxs PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxs OCA], [https://pdbe.org/4uxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uxs RCSB], [https://www.ebi.ac.uk/pdbsum/4uxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxs ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref>  The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref>  The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).  
[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4uxs" style="background-color:#fffaf0;"></div>
==See Also==
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Atherton, J]]
[[Category: Large Structures]]
[[Category: Farabella, I]]
[[Category: Atherton J]]
[[Category: Houdusse, A]]
[[Category: Farabella I]]
[[Category: Moores, C]]
[[Category: Houdusse A]]
[[Category: Rosenfeld, S S]]
[[Category: Moores C]]
[[Category: Topf, M]]
[[Category: Rosenfeld SS]]
[[Category: Yu, I M]]
[[Category: Topf M]]
[[Category: Cryo-em]]
[[Category: Yu IM]]
[[Category: Kinesin]]
[[Category: Microtubule]]
[[Category: Transport protein]]

Latest revision as of 11:24, 9 May 2024

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

4uxs, resolution 7.00Å

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