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==Mixed-function P450 MycG in complex with mycinamicin III in P21212 space group==
==Mixed-function P450 MycG in complex with mycinamicin III in P21212 space group==
<StructureSection load='2yca' size='340' side='right' caption='[[2yca]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2yca' size='340' side='right'caption='[[2yca]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Micromonospora_griseorubida Micromonospora griseorubida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YCA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_griseorubida Micromonospora griseorubida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YCA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=ZM3:MYCINAMICIN+III'>ZM3</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y5n|2y5n]], [[2y46|2y46]], [[2y5z|2y5z]], [[2y98|2y98]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=ZM3:MYCINAMICIN+III'>ZM3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yca OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yca RCSB], [http://www.ebi.ac.uk/pdbsum/2yca PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yca OCA], [https://pdbe.org/2yca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yca RCSB], [https://www.ebi.ac.uk/pdbsum/2yca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yca ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MYCG_MICGR MYCG_MICGR] Involved in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic. Catalyzes consecutive hydroxylation (at C14) and epoxidation (at C12-C13) reactions with mycinamicin IV as initial substrate, leading to mycinamicin II. These reactions require prior dimethylation of 6-deoxyallose to mycinose for effective conversion by the dual function MycG enzyme.<ref>PMID:18804032</ref> <ref>PMID:22547618</ref> <ref>PMID:7808395</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2yca" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Micromonospora griseorubida]]
[[Category: Micromonospora griseorubida]]
[[Category: Kells, P M]]
[[Category: Kells PM]]
[[Category: Li, S]]
[[Category: Li S]]
[[Category: Podust, L M]]
[[Category: Podust LM]]
[[Category: Sherman, D H]]
[[Category: Sherman DH]]
[[Category: Mycinamicin biosynthesis]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2yca"