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[[Image:2pgd.jpg|left|200px]]


{{Structure
==THE STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE REFINED AT 2 ANGSTROMS RESOLUTION==
|PDB= 2pgd |SIZE=350|CAPTION= <scene name='initialview01'>2pgd</scene>, resolution 2.&Aring;
<StructureSection load='2pgd' size='340' side='right'caption='[[2pgd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
<table><tr><td colspan='2'>[[2pgd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pgd 1pgd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PGD FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(decarboxylating) Phosphogluconate dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pgd OCA], [https://pdbe.org/2pgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pgd RCSB], [https://www.ebi.ac.uk/pdbsum/2pgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pgd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/6PGD_SHEEP 6PGD_SHEEP] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pg/2pgd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pgd ConSurf].
<div style="clear:both"></div>


'''THE STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE REFINED AT 2 ANGSTROMS RESOLUTION'''
==See Also==
 
*[[6-phosphogluconate dehydrogenase 3D structures|6-phosphogluconate dehydrogenase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The three-dimensional structure of ovine 6-phosphogluconate dehydrogenase, refined at 2.5 A resolution with a residual for all data of 18.5%, is reported. This model, based on improved diffraction data and a corrected sequence, supersedes that reported earlier. Each subunit of the dimer has three domains: a beta-alpha-beta domain binds NADP; an all alpha domain provides much of the dimer interface; the C-terminal tail burrows into the second subunit.
[[Category: Large Structures]]
 
==About this Structure==
2PGD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. This structure supersedes the now removed PDB entry 1PGD. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGD OCA].
 
==Reference==
The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A resolution., Adams MJ, Gover S, Leaback R, Phillips C, Somers DO, Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):817-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1793548 1793548]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
[[Category: Phosphogluconate dehydrogenase (decarboxylating)]]
[[Category: Adams MJ]]
[[Category: Single protein]]
[[Category: Gover S]]
[[Category: Adams, M J.]]
[[Category: Phillips C]]
[[Category: Gover, S.]]
[[Category: Phillips, C.]]
[[Category: SO4]]
[[Category: oxidoreductase (choh(d)-nadp+(a))]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:12:42 2008''

Latest revision as of 09:09, 21 February 2024

THE STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE REFINED AT 2 ANGSTROMS RESOLUTION

2pgd, resolution 2.00Å

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