4fgt: Difference between revisions
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==Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.== | ==Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.== | ||
<StructureSection load='4fgt' size='340' side='right' caption='[[4fgt]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4fgt' size='340' side='right'caption='[[4fgt]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fgt]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4fgt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FGT FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgt OCA], [https://pdbe.org/4fgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fgt RCSB], [https://www.ebi.ac.uk/pdbsum/4fgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fgt ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4fgt" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Costi | [[Category: Synthetic construct]] | ||
[[Category: Finer-Moore | [[Category: Costi MP]] | ||
[[Category: Stroud | [[Category: Finer-Moore J]] | ||
[[Category: Tochowicz | [[Category: Stroud RM]] | ||
[[Category: Tochowicz A]] | |||
Latest revision as of 06:57, 27 November 2024
Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.
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