4s2w: Difference between revisions
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New page: '''Unreleased structure''' The entry 4s2w is ON HOLD Authors: Vasilyev, N., Serganov, A. Description: Structure of E. coli RppH bound to sulfate ions [[Category: Unreleased Structures]... |
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==Structure of E. coli RppH bound to sulfate ions== | |||
<StructureSection load='4s2w' size='340' side='right'caption='[[4s2w]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4s2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S2W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.992Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: Serganov | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s2w OCA], [https://pdbe.org/4s2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s2w RCSB], [https://www.ebi.ac.uk/pdbsum/4s2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s2w ProSAT]</span></td></tr> | ||
[[Category: Vasilyev | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RPPH_ECOLI RPPH_ECOLI] Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.<ref>PMID:10760174</ref> <ref>PMID:18202662</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Serganov A]] | |||
[[Category: Vasilyev N]] | |||
