4y03: Difference between revisions

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'''Unreleased structure'''


The entry 4y03 is ON HOLD
==Crystal Structure of the fifth bromodomain of human PB1 in complex with salicylic acid==
 
<StructureSection load='4y03' size='340' side='right'caption='[[4y03]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4y03]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y03 FirstGlance]. <br>
Description: Crystal Structure of the fifth bromodomain of human PB1 in complex with salicylic acid
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
[[Category: Fedorov, O]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y03 OCA], [https://pdbe.org/4y03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y03 RCSB], [https://www.ebi.ac.uk/pdbsum/4y03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y03 ProSAT]</span></td></tr>
[[Category: Picaud, S]]
</table>
[[Category: Knapp, S]]
== Disease ==
[[Category: Bountra, C]]
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
[[Category: Felletar, I]]
== Function ==
[[Category: Arrowsmith, C.H]]
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
[[Category: Von Delft, F]]
== References ==
[[Category: Filippakopoulos, P]]
<references/>
[[Category: Edwards, A.M]]
__TOC__
[[Category: Structural Genomics Consortium (Sgc)]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: Fedorov O]]
[[Category: Felletar I]]
[[Category: Filippakopoulos P]]
[[Category: Knapp S]]
[[Category: Picaud S]]
[[Category: Von Delft F]]
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