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==Crystal structure of PBP2a from MRSA in complex with quinazolinone ligand==
==Crystal structure of PBP2a from MRSA in complex with quinazolinone ligand==
<StructureSection load='4cjn' size='340' side='right' caption='[[4cjn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4cjn' size='340' side='right'caption='[[4cjn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cjn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CJN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cjn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CJN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene>, <scene name='pdbligand=QNZ:(E)-3-(2-(4-CYANOSTYRYL)-4-OXOQUINAZOLIN-3(4H)-YL)BENZOIC+ACID'>QNZ</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.947&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene>, <scene name='pdbligand=QNZ:(E)-3-(2-(4-CYANOSTYRYL)-4-OXOQUINAZOLIN-3(4H)-YL)BENZOIC+ACID'>QNZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cjn RCSB], [http://www.ebi.ac.uk/pdbsum/4cjn PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cjn OCA], [https://pdbe.org/4cjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cjn RCSB], [https://www.ebi.ac.uk/pdbsum/4cjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cjn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0J9X1X5_STAAM A0A0J9X1X5_STAAM]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4cjn" style="background-color:#fffaf0;"></div>
==See Also==
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
[[Category: Large Structures]]
[[Category: Bouley, R]]
[[Category: Staphylococcus aureus subsp. aureus Mu50]]
[[Category: Hermoso, J A]]
[[Category: Bouley R]]
[[Category: Otero, L H]]
[[Category: Hermoso JA]]
[[Category: Rojas-Altuve, A]]
[[Category: Otero LH]]
[[Category: Allosteric site]]
[[Category: Rojas-Altuve A]]
[[Category: Hydrolase]]
[[Category: Immune system]]
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