2q5f: Difference between revisions

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[[Image:2q5f.jpg|left|200px]]


{{Structure
==Crystal structure of LMNADK1 from Listeria monocytogenes==
|PDB= 2q5f |SIZE=350|CAPTION= <scene name='initialview01'>2q5f</scene>, resolution 1.90&Aring;
<StructureSection load='2q5f' size='340' side='right'caption='[[2q5f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DTA:(2S,3S,4R,5R,2'S,3'S,4'R,5'R)-2,2'-[DITHIOBIS(METHYLENE)]BIS[5-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIOL]'>DTA</scene>
<table><tr><td colspan='2'>[[2q5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q5F FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE= ppnK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1639 Listeria monocytogenes])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTA:(2S,3S,4R,5R,2S,3S,4R,5R)-2,2-[DITHIOBIS(METHYLENE)]BIS[5-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIOL]'>DTA</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5f OCA], [https://pdbe.org/2q5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q5f RCSB], [https://www.ebi.ac.uk/pdbsum/2q5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q5f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q5f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q5f ConSurf].
<div style="clear:both"></div>


'''Crystal structure of LMNADK1 from Listeria monocytogenes'''
==See Also==
 
*[[NAD kinase|NAD kinase]]
 
== References ==
==About this Structure==
<references/>
2Q5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5F OCA].
__TOC__
[[Category: Listeria monocytogenes]]
</StructureSection>
[[Category: NAD(+) kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Listeria monocytogenes EGD-e]]
[[Category: Arold, S.]]
[[Category: Arold S]]
[[Category: Assairi, L.]]
[[Category: Assairi L]]
[[Category: Labesse, G.]]
[[Category: Labesse G]]
[[Category: Pochet, S.]]
[[Category: Pochet S]]
[[Category: Poncet-Montange, G.]]
[[Category: Poncet-Montange G]]
[[Category: DTA]]
[[Category: mutant]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:21:55 2008''
Retrieved from "https://proteopedia.org/2q5f"