2mz6: Difference between revisions
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==NMR structure of Protegrin-3 (PG3) in the presence of DPC micelles== | |||
<StructureSection load='2mz6' size='340' side='right'caption='[[2mz6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZ6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz6 OCA], [https://pdbe.org/2mz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mz6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PG3_PIG PG3_PIG] Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A tendency to dimerize in the presence of lipids was found for the protegrin. The dimer formation by the protegrin-1 (PG-1) is the first step for further oligomeric membrane pore formation. Generally there are two distinct model of PG-1 dimerization in either a parallel or antiparallel beta-sheet. But despite the wealth of data available today, protegrin dimer structure and pore formation is still not completely understood. In order to investigate a more detailed dimerization process of PG-1 and if it will be the same for another type of protegrins, in this work we used a high-resolution NMR spectroscopy for structure determination of protegrin-3 (RGGGL-CYCRR-RFCVC-VGR) in the presence of perdeuterated DPC micelles and demonstrate that PG-3 forms an antiparallel NCCN dimer with a possible association of these dimers. This structural study complements previously published solution, solid state and computational studies of PG-1 in various environments and validate the potential of mean force simulations of PG-1 dimers and association of dimers to form octameric or decameric beta-barrels. | |||
Antimicrobial peptide protegrin-3 adopt an antiparallel dimer in the presence of DPC micelles: a high-resolution NMR study.,Usachev KS, Efimov SV, Kolosova OA, Klochkova EA, Aganov AV, Klochkov VV J Biomol NMR. 2015 Mar 19. PMID:25786621<ref>PMID:25786621</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Aganov | <div class="pdbe-citations 2mz6" style="background-color:#fffaf0;"></div> | ||
[[Category: Efimov | |||
[[Category: | ==See Also== | ||
[[Category: Klochkova | *[[Protegrin|Protegrin]] | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sus scrofa]] | |||
[[Category: Aganov AV]] | |||
[[Category: Efimov SV]] | |||
[[Category: Klochkov VV]] | |||
[[Category: Klochkova EA]] | |||
[[Category: Kolosova OA]] | |||
[[Category: Usachev KS]] | |||
Latest revision as of 08:19, 30 October 2024
NMR structure of Protegrin-3 (PG3) in the presence of DPC micelles
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