4ydp: Difference between revisions
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New page: '''Unreleased structure''' The entry 4ydp is ON HOLD Authors: Grishkovskaya, I., Onipe, A., Kontaxis, G., Djinovic-Carugo, K. Description: Crystal structure of N-terminal PDZ domain of... |
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==Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.== | |||
<StructureSection load='4ydp' size='340' side='right'caption='[[4ydp]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ydp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YDP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ydp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydp OCA], [https://pdbe.org/4ydp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ydp RCSB], [https://www.ebi.ac.uk/pdbsum/4ydp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ydp ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/LDB3_HUMAN LDB3_HUMAN] Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:[https://omim.org/entry/601493 601493]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14662268</ref> <ref>PMID:14660611</ref> Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:[https://omim.org/entry/601493 601493]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle. Defects in LDB3 are the cause of myopathy myofibrillar type 4 (MFM4) [MIM:[https://omim.org/entry/609452 609452]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LDB3_HUMAN LDB3_HUMAN] May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.[:] | |||
==See Also== | |||
*[[PDZ and LIM domain protein|PDZ and LIM domain protein]] | |||
*[[ZASP protein|ZASP protein]] | |||
[[Category: | == References == | ||
[[Category: Djinovic-Carugo | <references/> | ||
[[Category: Grishkovskaya | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Djinovic-Carugo K]] | |||
[[Category: Grishkovskaya I]] | |||
[[Category: Kontaxis G]] | |||
[[Category: Onipe A]] | |||
Latest revision as of 10:54, 10 January 2024
Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.
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