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==Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with N-glycolylneuraminic acid==
==Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with N-glycolylneuraminic acid==
<StructureSection load='4qva' size='340' side='right' caption='[[4qva]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
<StructureSection load='4qva' size='340' side='right'caption='[[4qva]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qva]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QVA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_cat/GIV.2/CU081210E/USA/2010 Norovirus cat/GIV.2/CU081210E/USA/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QVA FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qv2|4qv2]], [[4quz|4quz]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qva RCSB], [http://www.ebi.ac.uk/pdbsum/4qva PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qva OCA], [https://pdbe.org/4qva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qva RCSB], [https://www.ebi.ac.uk/pdbsum/4qva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qva ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/H8YRY9_9CALI H8YRY9_9CALI]
Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35A resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain alpha-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.
 
Structural analysis of a feline norovirus protruding domain.,Singh BK, Glatt S, Ferrer JL, Koromyslova AD, Leuthold MM, Dunder J, Hansman GS Virology. 2015 Jan 1;474:181-5. doi: 10.1016/j.virol.2014.10.028. Epub 2014 Nov, 19. PMID:25463616<ref>PMID:25463616</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hansman, G S]]
[[Category: Large Structures]]
[[Category: Singh, B K]]
[[Category: Norovirus cat/GIV 2/CU081210E/USA/2010]]
[[Category: Feline norovirus]]
[[Category: Hansman GS]]
[[Category: P domain]]
[[Category: Singh BK]]
[[Category: Protruding domain]]
[[Category: Viral capsid protein]]
[[Category: Viral protein]]
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