4yhj: Difference between revisions

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'''Unreleased structure'''


The entry 4yhj is ON HOLD
==Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4 (GRK4)==
 
<StructureSection load='4yhj' size='340' side='right'caption='[[4yhj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
Authors: Allen, S.J., Parthasrathy, G., Soisson, S., Munshi, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4yhj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YHJ FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AN2:AMP+PHOSPHORAMIDATE'>AN2</scene></td></tr>
[[Category: Soisson, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yhj OCA], [https://pdbe.org/4yhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yhj RCSB], [https://www.ebi.ac.uk/pdbsum/4yhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yhj ProSAT]</span></td></tr>
[[Category: Munshi, S]]
</table>
[[Category: Parthasrathy, G]]
== Function ==
[[Category: Allen, S.J]]
[https://www.uniprot.org/uniprot/GRK4_HUMAN GRK4_HUMAN] Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.<ref>PMID:19520868</ref> <ref>PMID:8626439</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Allen SJ]]
[[Category: Munshi S]]
[[Category: Parthasarathy G]]
[[Category: Soisson S]]
Retrieved from "https://proteopedia.org/4yhj"