Cluster of Differentiation CD38: Difference between revisions

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{{STRUCTURE_3gc6|  PDB=3gc6  | SIZE=400| SCENE=Cluster_of_Differentiation_38/Cv/1 |right|CAPTION=Glycosylated Cluster of Differentiation 38 (CD38) complex with sulfate [[3gc6]] }}
<StructureSection load='2i65' size='450' side='right' scene='42/422415/Cv/3' caption='Human Cluster of Differentiation 38 (CD38) complex with NAD [[2i65]]'>


[[Cluster of Differentiation 38]] (CD38), known also as ''ADP-ribosyl cyclase 1'' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR).  It is found on the surface of immune cells.  It also functions in cell adhesion, signal transduction and Ca++ signaling.
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== Function ==


[[Cluster of Differentiation 38]] (CD38), known also as '''ADP-ribosyl cyclase 1''' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR).  It is found on the surface of immune cells.  It also functions in cell adhesion, signal transduction and Ca+2 signaling.  '''ADP-ribosyl cyclase''' (ADPRC) is the ''Aplysia californica'' homolog of CD38.  It  catalyzes the synthesis and hydrolysis of cyclic ADP-ribose.  It uses  NAD+ as substrate and produces cyclic ADP-ribose (cADPR).<ref>PMID:16154090</ref>
== Relevance ==
CD38 is used as a marker for cell activation and for leukemia.
== Structural highlights ==
<scene name='42/422415/Cv/4'>CD38 active site contains NAD</scene>.<ref>PMID:16951430</ref>
</StructureSection>
== 3D Structures of Cluster of Differentiation 38 ==
== 3D Structures of Cluster of Differentiation 38 ==
    
    
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**[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br />
**[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br />
**[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br />
**[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br />
**[[4cmh]] - hCD38 enzymatic domain + antibody<br />
**[[2i65]] – hCD38+NAD<br />
**[[2i65]] – hCD38+NAD<br />
**[[3kou]] - hCD38+NAD derivative<br />
**[[2i67]] - hCD38 (mutant)+ADPR<br />
**[[2i67]] - hCD38 (mutant)+ADPR<br />
**[[2hct]] -  hCD38 enzymatic domain (mutant)+NMN<br />
**[[2hct]] -  hCD38 enzymatic domain (mutant)+NMN<br />
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**[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br />
**[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br />
**[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br />
**[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br />
**[[1isf]] – hCD38 (mutant)<br />
**[[3p5s]] - bADPRC + arabinitol derivative<br />
 
*ADPRC
 
**[[1r12]] - AcADPRC - ''Aplysia californica''<br />
**[[1r0s]] – AcADPRC (mutant) <br />
 
*ADPRC+ligand
 
**[[1r15]] -  AcADPRC+nicotinamide<br />
**[[3i9j]] – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI<br />
**[[3i9k]] – AcADPRC (mutant)+NAD<br />
**[[3i9l]] – AcADPRC (mutant)+N1-CIDPR<br />
**[[3i9o]] – AcADPRC+Ribosyl-2F-ADPR<br />
**[[3zwx]], [[3zwy]] – AcADPRC + 8-Br-ADPR<br />
**[[1r16]] -  AcADPRC+3-pyridinylcarbinol<br />
**[[3zwm]] – AcADPRC + NAD + cADPR<br />
**[[3zwn]] – AcADPRC + NGD + cGDPR<br />
**[[3zwo]] – AcADPRC + NGD + GDPR<br />
**[[3zwp]], [[3zwv]], [[3zww]] – AcADPRC+ diphosphate ribosyl ara-2F-ADPR<br />
 
 
}}
}}
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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