2qxf: Difference between revisions

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[[Image:2qxf.jpg|left|200px]]


{{Structure
==Product bound structure of exonuclease I at 1.5 angstrom resolution==
|PDB= 2qxf |SIZE=350|CAPTION= <scene name='initialview01'>2qxf</scene>, resolution 1.50&Aring;
<StructureSection load='2qxf' size='340' side='right'caption='[[2qxf]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+2000'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+A+2001'>AC2</scene>, <scene name='pdbsite=AC3:Na+Binding+Site+For+Residue+A+2002'>AC3</scene> and <scene name='pdbsite=AC4:Tmp+Binding+Site+For+Residue+A+3000'>AC4</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=TMP:THYMIDINE-5'-PHOSPHATE'>TMP</scene>
<table><tr><td colspan='2'>[[2qxf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QXF FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
|GENE= sbcB, cpeA, xonA, b2011, JW1993 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K12])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxf OCA], [https://pdbe.org/2qxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qxf RCSB], [https://www.ebi.ac.uk/pdbsum/2qxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qxf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EX1_ECOLI EX1_ECOLI] Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/2qxf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qxf ConSurf].
<div style="clear:both"></div>


'''Product bound structure of exonuclease I at 1.5 angstrom resolution'''
==See Also==
 
*[[Exonuclease 3D structures|Exonuclease 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2QXF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXF OCA].
[[Category: Escherichia coli K-12]]
[[Category: Escherichia coli k12]]
[[Category: Large Structures]]
[[Category: Exodeoxyribonuclease I]]
[[Category: Busam RD]]
[[Category: Single protein]]
[[Category: Busam, R D.]]
[[Category: MG]]
[[Category: NA]]
[[Category: TMP]]
[[Category: alpha-beta domain]]
[[Category: dna damage]]
[[Category: dna repair]]
[[Category: dnaq superfamily]]
[[Category: exonuclease]]
[[Category: hydrolase]]
[[Category: nuclease]]
[[Category: product bound structure]]
[[Category: sh3-like domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:30:37 2008''

Latest revision as of 09:18, 21 February 2024

Product bound structure of exonuclease I at 1.5 angstrom resolution

2qxf, resolution 1.50Å

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