5amo: Difference between revisions

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'''Unreleased structure'''


The entry 5amo is ON HOLD  until Paper Publication
==Structure of a mouse Olfactomedin-1 disulfide-linked dimer of the Olfactomedin domain and part of the coiled coil==
<StructureSection load='5amo' size='340' side='right'caption='[[5amo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5amo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amo OCA], [https://pdbe.org/5amo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amo RCSB], [https://www.ebi.ac.uk/pdbsum/5amo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOE1_MOUSE NOE1_MOUSE] May play an important role in regulating the production of neural crest cells by the neural tube.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Olfactomedin-1 (Olfm1; also known as noelin, pancortin) is a member of the olfactomedin domain-containing superfamily and a highly expressed neuronal glycoprotein important for nervous system development. It binds a number of secreted proteins and cell-surface bound receptors to induce cell signaling processes. Using a combined approach of X-ray crystallography, solution scattering, analytical ultracentrifugation and electron microscopy we determine that full-length Olfm1 forms disulfide-linked tetramers with a distinctive V-shaped architecture. The base of the ''V'' is formed by two disulfide-linked dimeric N-terminal domains. Each of the two V-legs consists of a parallel dimeric disulfide-linked coiled coil with at the tips a C-terminal beta-propeller dimer. This agrees with our crystal structure of a C-terminal coiled-coil segment and beta-propeller combination (Olfm1coil-Olf), which reveals a disulfide-linked dimeric arrangement with the beta-propeller top faces in an outward exposed orientation. Similar to its family member myocilin, Olfm1 is stabilized by calcium. The dimer-of-dimers architecture suggests a role for Olfm1 in clustering receptors to regulate signaling and informs on the conformation of several other olfactomedin domain family members.


Authors: Pronker, M.F., Bos, G.A.A.A., Sharp, T.H., Thies-Weesie, D.M., Janssen, B.J.C.
Olfactomedin-1 has a V-shaped disulfide-linked tetrameric structure.,Pronker MF, Bos TG, Sharp TH, Thies-Weesie DM, Janssen BJ J Biol Chem. 2015 Apr 21. pii: jbc.M115.653485. PMID:25903135<ref>PMID:25903135</ref>


Description: Structure of a mouse Olfactomedin-1 disulfide-linked dimer of the Olfactomedin domain and part of the coiled coil
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Pronker, M.F]]
<div class="pdbe-citations 5amo" style="background-color:#fffaf0;"></div>
[[Category: Thies-Weesie, D.M]]
== References ==
[[Category: Janssen, B.J.C]]
<references/>
[[Category: Bos, G.A.A.A]]
__TOC__
[[Category: Sharp, T.H]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bos TGAA]]
[[Category: Janssen BJC]]
[[Category: Pronker MF]]
[[Category: Sharp TH]]
[[Category: Thies-Weesie DM]]
Retrieved from "https://proteopedia.org/5amo"