2r2p: Difference between revisions

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[[Image:2r2p.jpg|left|200px]]


{{Structure
==Kinase domain of human ephrin type-A receptor 5 (EphA5)==
|PDB= 2r2p |SIZE=350|CAPTION= <scene name='initialview01'>2r2p</scene>, resolution 2.40&Aring;
<StructureSection load='2r2p' size='340' side='right'caption='[[2r2p]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
<table><tr><td colspan='2'>[[2r2p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R2P FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= EPHA5, EHK1, HEK7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2p OCA], [https://pdbe.org/2r2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r2p RCSB], [https://www.ebi.ac.uk/pdbsum/2r2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r2p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EPHA5_HUMAN EPHA5_HUMAN] Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r2p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r2p ConSurf].
<div style="clear:both"></div>


'''Kinase domain of human ephrin type-A receptor 5 (EphA5)'''
==See Also==
 
*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2R2P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2P OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Butler-Cole C]]
[[Category: Butler-Cole, C.]]
[[Category: Cuerrier D]]
[[Category: Cuerrier, D.]]
[[Category: Dhe-Paganon S]]
[[Category: Dhe-Paganon, S.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Walker JR]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Walker, J R.]]
[[Category: Weigelt, J.]]
[[Category: CL]]
[[Category: SO4]]
[[Category: alternative splicing]]
[[Category: atp-binding]]
[[Category: glycoprotein]]
[[Category: kinase]]
[[Category: nucleotide-binding]]
[[Category: phosphorylation]]
[[Category: receptor]]
[[Category: sgc]]
[[Category: signal]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: transferase]]
[[Category: transmembrane]]
[[Category: tyrosine-protein kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:32:01 2008''

Latest revision as of 11:44, 30 August 2023

Kinase domain of human ephrin type-A receptor 5 (EphA5)

2r2p, resolution 2.40Å

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