4d2g: Difference between revisions
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==Crystal structure of human PCNA in complex with p15 peptide== | ==Crystal structure of human PCNA in complex with p15 peptide== | ||
<StructureSection load='4d2g' size='340' side='right' caption='[[4d2g]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='4d2g' size='340' side='right'caption='[[4d2g]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4d2g]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2G OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4d2g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D2G FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2g OCA], [https://pdbe.org/4d2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d2g RCSB], [https://www.ebi.ac.uk/pdbsum/4d2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d2g ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 15: | Line 17: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4d2g" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]] | |||
*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]] | |||
*[[User:LukáÃ
¡ Cakl/Sandbox 1|User:LukáÃ
¡ Cakl/Sandbox 1]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bernardo | [[Category: Homo sapiens]] | ||
[[Category: Blanco | [[Category: Large Structures]] | ||
[[Category: Castillo | [[Category: Synthetic construct]] | ||
[[Category: Cordeiro | [[Category: Bernardo P]] | ||
[[Category: DeBiasio | [[Category: Blanco FJ]] | ||
[[Category: Diercks | [[Category: Castillo F]] | ||
[[Category: Ibanez | [[Category: Cordeiro TN]] | ||
[[Category: Lelli | [[Category: DeBiasio A]] | ||
[[Category: Luque | [[Category: Diercks T]] | ||
[[Category: Merino | [[Category: Ibanez A]] | ||
[[Category: Molina | [[Category: Lelli M]] | ||
[[Category: Montoya | [[Category: Luque I]] | ||
[[Category: Mortuza | [[Category: Merino N]] | ||
[[Category: Villate | [[Category: Molina R]] | ||
[[Category: Montoya G]] | |||
[[Category: Mortuza G]] | |||
[[Category: Villate M]] | |||
