4ys7: Difference between revisions
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New page: '''Unreleased structure''' The entry 4ys7 is ON HOLD Authors: Burdi, D.F., Herman, L., Wang, T. Description: Category: Unreleased Structures Category: Burdi, D.F [[Category: W... |
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==Co-crystal structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3H-imidazo[4,5-f]quinoline (compound 39) with PDE10A== | |||
<StructureSection load='4ys7' size='340' side='right'caption='[[4ys7]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ys7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YS7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GK:2-[2-(5,8-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-2-YL)ETHYL]-3-METHYL-3H-IMIDAZO[4,5-F]QUINOLINE'>4GK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ys7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ys7 OCA], [https://pdbe.org/4ys7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ys7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ys7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ys7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==See Also== | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Burdi | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Burdi DF]] | |||
[[Category: Herman L]] | |||
[[Category: Wang T]] | |||
Latest revision as of 13:04, 1 March 2024
Co-crystal structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3H-imidazo[4,5-f]quinoline (compound 39) with PDE10A
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