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==NMR structure of Protegrin-3 (PG3) in the presence of DPC micelles==
==NMR structure of Protegrin-3 (PG3) in the presence of DPC micelles==
<StructureSection load='2mz6' size='340' side='right' caption='[[2mz6]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2mz6' size='340' side='right'caption='[[2mz6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mz6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MZ6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZ6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mz5|2mz5]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2mz6 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz6 OCA], [https://pdbe.org/2mz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mz6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PG3_PIG PG3_PIG]] Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.  
[https://www.uniprot.org/uniprot/PG3_PIG PG3_PIG] Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A tendency to dimerize in the presence of lipids was found for the protegrin. The dimer formation by the protegrin-1 (PG-1) is the first step for further oligomeric membrane pore formation. Generally there are two distinct model of PG-1 dimerization in either a parallel or antiparallel beta-sheet. But despite the wealth of data available today, protegrin dimer structure and pore formation is still not completely understood. In order to investigate a more detailed dimerization process of PG-1 and if it will be the same for another type of protegrins, in this work we used a high-resolution NMR spectroscopy for structure determination of protegrin-3 (RGGGL-CYCRR-RFCVC-VGR) in the presence of perdeuterated DPC micelles and demonstrate that PG-3 forms an antiparallel NCCN dimer with a possible association of these dimers. This structural study complements previously published solution, solid state and computational studies of PG-1 in various environments and validate the potential of mean force simulations of PG-1 dimers and association of dimers to form octameric or decameric beta-barrels.
 
Antimicrobial peptide protegrin-3 adopt an antiparallel dimer in the presence of DPC micelles: a high-resolution NMR study.,Usachev KS, Efimov SV, Kolosova OA, Klochkova EA, Aganov AV, Klochkov VV J Biomol NMR. 2015 Mar 19. PMID:25786621<ref>PMID:25786621</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mz6" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Protegrin|Protegrin]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aganov, A V]]
[[Category: Large Structures]]
[[Category: Efimov, S V]]
[[Category: Sus scrofa]]
[[Category: Klochkov, V V]]
[[Category: Aganov AV]]
[[Category: Klochkova, E A]]
[[Category: Efimov SV]]
[[Category: Kolosova, O A]]
[[Category: Klochkov VV]]
[[Category: Usachev, K S]]
[[Category: Klochkova EA]]
[[Category: Antimicrobial protein]]
[[Category: Kolosova OA]]
[[Category: Dimer]]
[[Category: Usachev KS]]
[[Category: Dpc micelle]]
[[Category: Protegrin]]
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