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==Structure of the Mycobacterium tuberculosis Type II Dehydroquinase N12S mutant (Crystal Form 2)==
==Structure of the Mycobacterium tuberculosis Type II Dehydroquinase N12S mutant (Crystal Form 2)==
<StructureSection load='4ckx' size='340' side='right' caption='[[4ckx]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4ckx' size='340' side='right'caption='[[4ckx]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ckx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CKX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ckx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CKX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ckw|4ckw]], [[4cky|4cky]], [[4ckz|4ckz]], [[4cl0|4cl0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ckx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ckx OCA], [https://pdbe.org/4ckx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ckx RCSB], [https://www.ebi.ac.uk/pdbsum/4ckx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ckx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ckx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ckx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ckx RCSB], [http://www.ebi.ac.uk/pdbsum/4ckx PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]  
[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
 
==See Also==
*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3-dehydroquinate dehydratase]]
[[Category: Large Structures]]
[[Category: Gonzalez-Bello, C]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Hawkins, A R]]
[[Category: Gonzalez-Bello C]]
[[Category: Lamb, H]]
[[Category: Hawkins AR]]
[[Category: Llamas-Saiz, A L]]
[[Category: Lamb H]]
[[Category: Maneiro, M]]
[[Category: Llamas-Saiz AL]]
[[Category: Otero, J M]]
[[Category: Maneiro M]]
[[Category: Peon, A]]
[[Category: Otero JM]]
[[Category: Raaij, M J.van]]
[[Category: Peon A]]
[[Category: Sedes, A]]
[[Category: Sedes A]]
[[Category: Bacterial protein]]
[[Category: Van Raaij MJ]]
[[Category: Binding site]]
[[Category: Inhibitor]]
[[Category: Lyase]]
[[Category: Protein binding]]
[[Category: Shikimis acid pathway]]
[[Category: Substrate specificity]]
[[Category: Type 2 dehydroquinase]]
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