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[[Image:2rlu.jpg|left|200px]]


{{Structure
==The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB==
|PDB= 2rlu |SIZE=350|CAPTION= <scene name='initialview01'>2rlu</scene>
<StructureSection load='2rlu' size='340' side='right'caption='[[2rlu]]' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[2rlu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RLU FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlu OCA], [https://pdbe.org/2rlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rlu RCSB], [https://www.ebi.ac.uk/pdbsum/2rlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlu ProSAT]</span></td></tr>
}}
</table>
 
__TOC__
'''The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Amborski AN]]
==Overview==
[[Category: Beribisky AV]]
Incorporation of the amino acid selenocysteine into a growing protein chain involves the interaction between a hairpin in the mRNA termed the selenocysteine insertion sequence (SECIS) and the special elongation factor SelB. Here we present the structure of the SECIS from the thermophilic organism Moorella thermoacetica (SECIS-MT) determined using nuclear magnetic resonance (NMR) spectroscopy. The SECIS-MT hairpin structure contains a pentaloop with the first and fourth nucleotides of the loop forming a noncanonical GC base pair; the fifth loop nucleotide is bulged out and unstructured. The G and U in positions two and three are on opposite sides of the loop and solvent exposed. The backbone resonances of the SECIS-binding domain from the M. thermoacetica SelB protein were assigned, and the degree of chemical shift perturbations that occur upon SECIS binding were mapped onto the structure of the complex. We demonstrate that a region in the third winged-helix domain of SelB, not previously implicated in binding, is affected by SECIS binding.
[[Category: Johnson AE]]
 
[[Category: Johnson PE]]
==About this Structure==
[[Category: Mark TL]]
2RLU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLU OCA].  
[[Category: Motamed M]]
 
[[Category: Tavares TJ]]
==Reference==
The three-dimensional structure of the Moorella thermoacetica selenocysteine insertion sequence RNA hairpin and its interaction with the elongation factor SelB., Beribisky AV, Tavares TJ, Amborski AN, Motamed M, Johnson AE, Mark TL, Johnson PE, RNA. 2007 Nov;13(11):1948-56. Epub 2007 Sep 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17901155 17901155]
[[Category: Single protein]]
[[Category: Amborski, A N.]]
[[Category: Beribisky, A V.]]
[[Category: Johnson, A E.]]
[[Category: Johnson, P E.]]
[[Category: Mark, T L.]]
[[Category: Motamed, M.]]
[[Category: Tavares, T J.]]
[[Category: nmr]]
[[Category: protein-rna interaction]]
[[Category: rna strcuture]]
[[Category: selb]]
[[Category: selenocysteine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:37:24 2008''

Latest revision as of 07:05, 1 May 2024

The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB

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