4q6s: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4q6s is ~~ON HOLD until Apr 29 2016~~

==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==

~~Authors~~: ~~Amacher~~, J.F., ~~Madden~~, D.R.

== Structural highlights ==

<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4Q6S FirstGlance].

~~Description~~: ~~CFTR Associated Ligand~~ (~~CAL~~) ~~PDZ bound to biotinylated peptide BT~~-L-~~iCAL36~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>

[[Category: Amacher~~, J.F~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [https://pdbe.org/4q6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [https://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</td></tr>

[[Category: Madden~~, D.R~~]]

</table>

== Disease ==

[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>

== Function ==

[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Amacher JF]]

[[Category: Madden DR]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4q6s is ON HOLD  until Apr 29 2016
+==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==
+<StructureSection load='4q6s' size='340' side='right'caption='[[4q6s]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-Authors: Amacher, J.F., Madden, D.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>
-Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
-[[Category: Amacher, J.F]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [https://pdbe.org/4q6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [https://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>
-[[Category: Madden, D.R]]
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Amacher JF]]
+[[Category: Madden DR]]