4z53: Difference between revisions

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'''Unreleased structure'''


The entry 4z53 is ON HOLD
==Quinolone(Trovafloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae==
<StructureSection load='4z53' size='340' side='right'caption='[[4z53]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4z53]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z53 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.26&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TR6:TROVAFLOXACIN'>TR6</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z53 OCA], [https://pdbe.org/4z53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z53 RCSB], [https://www.ebi.ac.uk/pdbsum/4z53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z53 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [https://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>


Authors: Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R.
==See Also==
 
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
Description: Quinolone(Trovafloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Fisher, L.M]]
__TOC__
[[Category: Selvarajah, J]]
</StructureSection>
[[Category: Laponogov, I]]
[[Category: Escherichia coli]]
[[Category: Pan, X.-S]]
[[Category: Large Structures]]
[[Category: Sanderson, M.R]]
[[Category: Streptococcus pneumoniae TIGR4]]
[[Category: Veselkov, D.A]]
[[Category: Crevel IM-T]]
[[Category: Crevel, I.M.-T]]
[[Category: Fisher LM]]
[[Category: Laponogov I]]
[[Category: Pan X-S]]
[[Category: Sanderson MR]]
[[Category: Selvarajah J]]
[[Category: Veselkov DA]]
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