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==LRIG1 extracellular domain: Structure and Function Analysis==
==LRIG1 extracellular domain: Structure and Function Analysis==
<StructureSection load='4u7m' size='340' side='right' caption='[[4u7m]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
<StructureSection load='4u7m' size='340' side='right'caption='[[4u7m]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4u7m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7M FirstGlance]. <br>
<table><tr><td colspan='2'>[[4u7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U7M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.757&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u7l|4u7l]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u7m RCSB], [http://www.ebi.ac.uk/pdbsum/4u7m PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7m OCA], [https://pdbe.org/4u7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u7m RCSB], [https://www.ebi.ac.uk/pdbsum/4u7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LRIG1_HUMAN LRIG1_HUMAN]] Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.<ref>PMID:15282549</ref>
[https://www.uniprot.org/uniprot/LRIG1_HUMAN LRIG1_HUMAN] Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.<ref>PMID:15282549</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4u7m" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Xu, Y]]
[[Category: Homo sapiens]]
[[Category: Egfr inhibition]]
[[Category: Large Structures]]
[[Category: Signaling protein]]
[[Category: Xu Y]]
[[Category: Stem cell marker]]
Retrieved from "https://proteopedia.org/4u7m"