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==Crystal structure of Arabidopsis thaliana ThiC with bound imidazole ribonucleotide and Fe==
==Crystal structure of Arabidopsis thaliana ThiC with bound imidazole ribonucleotide and Fe==
<StructureSection load='4s29' size='340' side='right' caption='[[4s29]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
<StructureSection load='4s29' size='340' side='right'caption='[[4s29]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4s29]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S29 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4s29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S29 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=IRN:1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE'>IRN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.382&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n7q|4n7q]], [[3epm|3epm]], [[3epn|3epn]], [[3epo|3epo]], [[4s25|4s25]], [[4s26|4s26]], [[4s27|4s27]], [[4s28|4s28]], [[4s2a|4s2a]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=IRN:1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE'>IRN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphomethylpyrimidine_synthase Phosphomethylpyrimidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.99.17 4.1.99.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s29 OCA], [https://pdbe.org/4s29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s29 RCSB], [https://www.ebi.ac.uk/pdbsum/4s29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s29 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s29 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s29 RCSB], [http://www.ebi.ac.uk/pdbsum/4s29 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THIC_ARATH THIC_ARATH]] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18048325</ref> <ref>PMID:18332905</ref>
[https://www.uniprot.org/uniprot/THIC_ARATH THIC_ARATH] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18048325</ref> <ref>PMID:18332905</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4s29" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phosphomethylpyrimidine synthase]]
[[Category: Arabidopsis thaliana]]
[[Category: Abdelwahed, S]]
[[Category: Large Structures]]
[[Category: Begley, T P]]
[[Category: Abdelwahed S]]
[[Category: Ealick, S E]]
[[Category: Begley TP]]
[[Category: Fenwick, M K]]
[[Category: Ealick SE]]
[[Category: Mehta, A P]]
[[Category: Fenwick MK]]
[[Category: Zhang, Y]]
[[Category: Mehta AP]]
[[Category: Adomet and glutamate mutase]]
[[Category: Zhang Y]]
[[Category: Alpha-beta barrel]]
[[Category: Domain swapping]]
[[Category: Iron-sulfur cluster]]
[[Category: Lyase]]
[[Category: Radical sam superfamily]]
[[Category: Thiamin]]
[[Category: Vitamin b1]]
[[Category: Vitamin b12]]
Retrieved from "https://proteopedia.org/4s29"