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==MPS1 kinase with 3-aminopyridin-2-one inhibitors==
==MPS1 kinase with 3-aminopyridin-2-one inhibitors==
<StructureSection load='4cva' size='340' side='right' caption='[[4cva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4cva' size='340' side='right'caption='[[4cva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cva]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CVA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WBI:N-(6-OXO-1,6-DIHYDRO-3,4-BIPYRIDIN-5-YL)-4-(PIPERIDIN-1-YL)BENZAMIDE'>WBI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=WBI:N-(6-OXO-1,6-DIHYDRO-3,4-BIPYRIDIN-5-YL)-4-(PIPERIDIN-1-YL)BENZAMIDE'>WBI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cv8|4cv8]], [[4cv9|4cv9]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cva OCA], [https://pdbe.org/4cva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cva RCSB], [https://www.ebi.ac.uk/pdbsum/4cva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cva ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cva RCSB], [http://www.ebi.ac.uk/pdbsum/4cva PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  
 
==See Also==
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Bavetsias, V]]
[[Category: Large Structures]]
[[Category: Bayliss, R]]
[[Category: Bavetsias V]]
[[Category: Fearon, D]]
[[Category: Bayliss R]]
[[Category: Jones, K]]
[[Category: Fearon D]]
[[Category: Schmitt, J]]
[[Category: Jones K]]
[[Category: Westwood, I M]]
[[Category: Schmitt J]]
[[Category: VanMontfort, R L.M]]
[[Category: Westwood IM]]
[[Category: Fragment]]
[[Category: VanMontfort RLM]]
[[Category: Inhibitor]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4cva"